Repair.  Regenerate. Renew.

Both are regenerative injectables, but they work through distinct mechanisms. Profhilo is high-concentration hyaluronic acid that spreads through tissue, providing deep hydration and stimulating collagen and elastin through bio-remodelling. Polynucleotides are DNA-fragment treatments that activate cellular repair, fibroblast activity, and tissue oxygenation through a receptor-mediated pathway. Profhilo’s primary effect is hydration and broad remodelling; polynucleotides’ primary effect is regeneration, particularly suited to under-eye concerns and damaged or scarred skin. They combine beautifully — Profhilo optimises the tissue environment while polynucleotides trigger cellular repair.

The purification process removes all allergenic proteins, leaving only nucleotide chains that are highly biocompatible with human tissue. Adverse reactions are extremely rare. We take a full allergy and medical history at consultation. A patch test can be arranged for patients with significant allergy concerns, though it is rarely necessary. Fish allergy is listed as a contraindication as a precaution.

A typical initial course is 3–4 sessions spaced 2–4 weeks apart. Patients with more significant concerns — under-eye deterioration, established scarring, or hair thinning — may benefit from up to 6 sessions. Maintenance is then recommended every 3–6 months to sustain results. Single treatments provide some benefit but do not replicate the cumulative regenerative effect of a full course.

Early improvements — increased hydration, a subtle glow, initial texture refinement — typically appear within 2–3 weeks of the first session. Meaningful structural improvement becomes visible around sessions 2–3 as collagen synthesis accumulates. Peak results emerge 4–8 weeks after completing the initial course. Results are progressive and cumulative, not instant.

Yes — polynucleotides are considered one of the safest treatments for the periorbital zone. Unlike hyaluronic acid fillers, there is no risk of Tyndall effect (bluish discolouration), migration, or vascular occlusion. The intradermal injection technique in this area is precise and carries a low complication profile when performed by an experienced practitioner. This safety advantage is a key reason polynucleotides have become a preferred under-eye treatment.

For early-stage androgenic alopecia and diffuse thinning, scalp polynucleotide injections can improve the follicular microenvironment, reduce scalp inflammation, and stimulate dormant follicles. Results are not equivalent to advanced hair restoration procedures, but for early intervention or as a complement to oral and topical treatments, clinical evidence is promising. A course of 4–6 sessions is typically recommended for scalp treatment.

Absolutely. Common and effective combinations include: with Profhilo for a layered regenerative approach; with micro-needling for enhanced absorption and accelerated scar improvement (spaced 2 weeks apart); with dermal fillers, where polynucleotides improve tissue quality first and fillers then address volume (sequential approach recommended); and with anti-wrinkle injections, which can be performed simultaneously or close together. Polynucleotides frequently serve as a regenerative foundation within comprehensive treatment programmes.